Hadley, Don
National Center for Human Genome Research and National
Cancer Institute, NIH
Bethesda, Maryland
Protocol # 95HG0165 (Funded by NCHGR Intramural Program.
Member of CGSC)
Project period: 9/95 - 9/98
Implication: Social SED
Individuals with colon cancer and/or polyps and their first degree
relatives will be offered gene testing for Hereditary Non-Polyposis
Colorectal Cancer. This study proposes to evaluate psychological and
behavioral aspects of their decision-making and the outcomes of the
testing process. Knowledge and expectations will be assessed initially,
followed by pre-test psychological assessment and an education and
counseling session. Participants will be presented the choice of whether
or not to undergo gene testing at a point when mutational analysis becomes
accurate and reliable. Notification of test results will occur in person
along with discussion of available surveillance options. Follow-up
counseling evaluation and support will be provided. Psychological and
behavioral outcomes will be reassessed at multiple time points following
disclosure.